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Updated: Jun 17, 2026

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
Published on: September 18, 2016
Functional specialization of antigen presenting cells in the gastrointestinal tract
1European Institute of Oncology, Department of Experimental Oncology, via Adamello 16, 20139 Milan, Italy. maria.rescigno@ifom-ieo-campus.it
Abstract:
Recent advances have highlighted that antigen presentation in the gastrointestinal tract is carried out by different specialized immune and non-immune cells. This is required in order to achieve tolerance towards self and non-self harmless antigens and immunity towards pathogenic microorganisms. In this review we will discuss the role of different players in these responses, including dendritic cells, macrophages, B cells and basophils as professional antigen presenting cells (APCs), and stromal cells and epithelial cells as non-professional APCs. The interaction between these cell types is required for the dynamic regulation of the immune response.
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