Plasma soluble corin in patients with heart failure
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Updated: Jun 17, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Ningzheng Dong1, Shenghan Chen, Junhua Yang
1Department of Cardiology, Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, Suzhou, China.
Insights
Plasma corin levels are significantly reduced in patients with heart failure (HF), but not acute myocardial infarction. This suggests corin deficiency may contribute to HF pathogenesis and plasma corin could be an HF diagnostic biomarker.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Corin is a transmembrane protease crucial for processing natriuretic peptides in the heart.
- Corin, like other membrane proteins, can be shed from the cell surface into circulation.
Purpose of the Study:
- To investigate plasma levels of soluble corin in healthy individuals and patients with heart failure (HF) or acute myocardial infarction.
- To determine the potential of plasma corin as a biomarker for HF diagnosis.
Main Methods:
- Plasma samples were collected from healthy controls (n=198), HF patients (n=291), and acute myocardial infarction patients (n=73).
- Soluble corin levels were quantified using an enzyme-linked immunosorbent assay (ELISA).
Main Results:
- Healthy adults exhibited plasma corin levels of 690 pg/mL (SD, 260 pg/mL).
- HF patients showed significantly lower plasma corin levels (365 pg/mL [SD, 259]; P<0.001), with levels decreasing as HF severity increased (NYHA classes II, III, IV).
- Plasma corin levels in acute myocardial infarction patients were comparable to healthy controls (678 pg/mL [SD, 285 pg/mL]; P>0.05).
Conclusions:
- Soluble corin is detectable in human plasma.
- Reduced plasma corin levels are associated with heart failure but not acute myocardial infarction.
- Plasma corin may serve as a valuable biomarker for diagnosing heart failure and warrants further investigation into its role in HF pathogenesis.
Background:
Corin is a transmembrane protease that processes natriuretic peptides in the heart. Like many membrane proteins, corin is shed from the cell surface.
Methods And Results:
In this study, we obtained plasma samples from healthy controls and patients with heart failure (HF) and acute myocardial infarction. Soluble corin levels in plasma were measured by an ELISA method. In healthy adults (n=198), plasma corin levels were 690 pg/mL (SD, 260 pg/mL). The corin levels did not differ significantly among different age groups. In patients with HF (n=291), plasma corin levels were significantly lower compared with that of healthy controls (365 pg/mL [SD, 259]; P<0.001). The reduction in plasma corin levels seemed to correlate with the severity of HF. In patients of New York Heart Association classes II, III, and IV, plasma corin levels were 450 pg/mL (SD, 281 pg/mL; n=69), 377 pg/mL (SD, 270 pg/mL; n=132), and 282 pg/mL (SD, 194 pg/mL; n=90), respectively (P<0.001 class II vs class IV; P<0.05 class III vs class IV). In contrast, plasma corin levels in patients with acute myocardial infarction (n=73) were similar to that of healthy controls (678 pg/mL [SD, 285 pg/mL]; P>0.05).
Conclusions:
Soluble corin was detected in human plasma. Plasma corin levels were reduced significantly in patients with HF but not in those with acute myocardial infarction. Our results indicate that corin deficiency may contribute to the pathogenesis of HF and that plasma corin may be used as a biomarker in the diagnosis of HF.
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