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Related Experiment Video

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Screening Assay for Oxidative Stress in a Feline Astrocyte Cell Line, G355-5
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Published on: July 13, 2011

Uric acid as a CNS antioxidant.

Gene L Bowman1, Jackilen Shannon, Balz Frei

  • 1Department of Neurology, Layton Center for Aging and Alzheimer's Disease Research, Oregon Health & Science University, Portland, OR 97239, USA. bowmang@ohsu.edu

Journal of Alzheimer'S Disease : JAD
|January 12, 2010
PubMed
Summary

Cerebrospinal fluid uric acid (UA) levels correlate with plasma UA and blood-brain barrier integrity in Alzheimer

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Gerontology

Background:

  • Oxidative damage is implicated in central nervous system (CNS) disorders.
  • Uric acid (UA) is a key hydrophilic antioxidant, influenced by diet and medication.
  • Limited research exists on CNS uric acid levels and their role in neurological diseases.

Purpose of the Study:

  • To investigate the relationship between cerebrospinal fluid (CSF) UA and plasma UA.
  • To determine if blood-brain barrier (BBB) integrity affects CSF UA levels.
  • To explore the association between CSF UA and cognitive decline rate in Alzheimer's disease (AD) patients.
  • To examine the potential interaction between UA and ascorbic acid in the brain.

Main Methods:

  • A longitudinal biomarker study involving 32 patients with mild to moderate AD.
  • Collection of CSF and blood samples at baseline for UA, ascorbic acid, and albumin.
  • Standardized clinical and cognitive assessments at baseline and one-year follow-up.

Main Results:

  • CSF UA levels were positively correlated with plasma UA (r=0.669, p=0.001).
  • Impaired BBB integrity was associated with elevated CSF UA levels (p=0.028).
  • CSF UA and CSF ascorbic acid showed a positive correlation (r=0.388, p=0.001).
  • Neither plasma nor CSF UA significantly correlated with the rate of cognitive decline over one year.

Conclusions:

  • The study supports the hypothesis that CSF UA is influenced by plasma UA and BBB integrity.
  • A significant association between UA and ascorbic acid was observed in CSF, but not plasma.
  • Further large-scale studies are needed to evaluate UA's potential in AD prevention.