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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

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Related Experiment Video

Updated: Jun 17, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
05:19

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

Molecular screening for bladder cancer: progress and potential.

Anirban P Mitra1, Richard J Cote

  • 1Department of Pathology, Keck School of Medicine, University of Southern California, Health Sciences Campus, 2011 Zonal Avenue, HMR 308, Los Angeles, CA 90033, USA.

Nature Reviews. Urology
|January 12, 2010
PubMed
Summary
This summary is machine-generated.

Bladder cancer screening can be improved using molecular tests combined with traditional methods. This approach targets high-risk individuals for early detection of urothelial carcinoma.

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An Orthotopic Bladder Cancer Model for Gene Delivery Studies
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An Orthotopic Bladder Cancer Model for Gene Delivery Studies

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Last Updated: Jun 17, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
05:19

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Area of Science:

  • Oncology
  • Urology
  • Molecular Diagnostics

Background:

  • Bladder cancer (urothelial carcinoma) is a significant cause of morbidity and mortality.
  • Current screening methods like urine cytology and microhematuria testing have limitations as standalone techniques.
  • Molecular alterations in urine offer potential for sensitive and specific bladder cancer detection.

Purpose of the Study:

  • To evaluate the potential of novel molecular screening modalities for urothelial carcinoma.
  • To propose an evidence-based and risk-based strategy for future bladder cancer screening.
  • To improve early detection and surveillance of bladder tumors.

Main Methods:

  • Review of traditional noninvasive diagnostic procedures (microhematuria testing, urine cytology).
  • Assessment of new qualitative and quantitative molecular screening assays detecting cellular/subcellular alterations in urine.
  • Analysis of combined approaches using molecular assays with traditional methods.

Main Results:

  • Molecular screening modalities show reasonable sensitivity and specificity for detecting urothelial carcinoma via urine.
  • Combining molecular assays with traditional methods yields promising results for bladder cancer detection.
  • An integrated approach can identify susceptible individuals and detect tumors early.

Conclusions:

  • A combined, risk-based screening approach utilizing microhematuria testing and specific molecular assays is proposed.
  • This strategy aims to detect bladder cancer before invasion using cost-effective, unobtrusive methods.
  • Optimizing surveillance for long-term follow-up is a key goal for managing urothelial carcinoma.