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Updated: Jun 17, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
Morphine-induced hallucinations - resolution with switching to oxycodone: a case report and review of the literature
Mursheda Mahbub Chowdhury1, Richard Board
1Department of Palliative Medicine, St Michael's Hospice, 25 Upper Maze Hill, St Leonard's-on-Sea, East Sussex TN38 0LB, UK.
Abstract:
Palliation of pain with morphine in cancer patients can be complicated by adverse effects. Tolerance to these effects such as nausea and drowsiness usually occurs within a few days allowing continuation of morphine therapy. However, some patients may develop intolerable adverse effects even after several months on morphine when the dose is increased. A case of morphine-induced hallucinations in a cancer patient who had been on a subcutaneous infusion of diamorphine for several months is discussed. A switch to oxycodone resolved his hallucinations and gave him a new lease of life. The theories behind and evidence for opioid-switching is discussed along with strategies for dealing with intolerable opioid-induced adverse effects.
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