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Inflammatory Bowel Disease II: Crohn's Disease

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

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Chronic Pancreatitis II: Collaborative Care

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Inflammatory Bowel Disease III: Crohn's Disease

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

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Updated: Jun 17, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Celiac disease with a mixed pattern: a case report.

Yalcin Basaran¹, Ismail Simsek, Armagan Gunal

¹Department of Internal Medicine, Gulhane Military Medical Academy, Tevfik Saglam Street, Ankara, 06010, Turkey.

|January 12, 2010

Summary

This summary is machine-generated.

Celiac disease, a severe autoimmune disorder, can lead to collagenous sprue, a condition of subepithelial collagen deposition. This case highlights the importance of considering celiac disease in patients with chronic diarrhea and malabsorption.

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Last Updated: Jun 17, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Area of Science:

Gastroenterology
Immunology
Pathology

Background:

Celiac disease is a severe autoimmune disorder with potential for progressive malabsorption and mortality.
A subset of celiac disease patients may develop subepithelial collagen deposition, termed collagenous sprue.
Collagenous sprue represents a distinct pathological finding in the gastrointestinal tract.

Purpose of the Study:

To report a case of celiac disease co-occurring with collagenous sprue.
To discuss the diagnostic challenges and differential considerations for malabsorptive disorders.
To emphasize the association between celiac disease and collagenous sprue.

Main Methods:

Case report of a 46-year-old female patient.
Review of patient's prior diagnoses: seronegative arthritis and inflammatory bowel disease.
Histological confirmation of celiac disease and collagenous sprue.

Main Results:

The patient was initially diagnosed with seronegative arthritis and inflammatory bowel disease.
Three years post-initial diagnosis, histological examination confirmed celiac disease.
The patient also presented with collagenous sprue, indicating a co-existing malabsorptive disorder.

Conclusions:

The relationship between celiac disease and collagenous sprue is debated but clinically significant.
Collagenous sprue should be considered in the differential diagnosis of chronic diarrhea.
Early recognition and diagnosis of celiac disease are crucial for managing progressive malabsorption.