Related Experiment Video
Updated: Jun 17, 2026

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
Published on: September 20, 2021
An immunocompetent patient presenting with severe nasal herpes simplex: a case report
Harry Rf Powell1, John Almeyda
1Ear Nose and Throat Department, West Middlesex University Hospital NHS Trust, Twickenham Road, Isleworth, Middlesex, TW7 6AF, UK.
Background:
Cutaneous manifestations of common viral pathogens or disease processes more common in immunocompromised individuals need to be considered when assessing patients with unusual clinical presentations. To our knowledge this is the first published case of severe nasal herpes simplex infection in an immunocompetent individual.
Case Presentation:
A 27-year-old Burmese woman presented to the Accident and Emergency department with increasing facial pain and fever having sustained local trauma to her nose 7 days prior. Despite 5 days of treatment with oral Amoxicillin 500 mg TDS and topical Neomycin sulphate cream the patient developed blistering followed by de-epithelialisation of the nasal skin.
Conclusion:
Herpes simplex virus is very common, occasionally patients present with severe and potentially disfiguring lesions. This case is important for any sub specialists dealing with facial lesions. Early accurate diagnosis can improve outcome and reduce long-term morbidity.
Related Concept Videos
Herpes
Genital Herpes
Cytomegalovirus Disease
Chickenpox
Cryptococcal Meningitis
Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
