Related Experiment Videos
Lanthanum associated abnormal liver function tests in two patients on dialysis: a case report
Girish Namagondlu1, Norman Main, Lucy Yates
1Department of Nephrology, Arrowe Park University Teaching Hospital NHS Foundation Trust, UK.
Journal of Medical Case Reports
|January 12, 2010
Summary
Lanthanum (La), a phosphate binder for dialysis patients, may cause abnormal liver function tests. This rare adverse reaction is reported for the first time in patients undergoing renal replacement therapy.
Area of Science:
- Nephrology
- Pharmacology
- Hepatology
Background:
- Lanthanum (La) is a phosphate binder prescribed for dialysis patients in the UK.
- Long-term safety data for lanthanum in renal failure patients on renal replacement therapy are limited.
- Known adverse reactions to lanthanum include nausea, sickness, dialysis graft occlusion, and abdominal pain.
Purpose of the Study:
- To report the first occurrence of lanthanum-induced abnormal liver function tests in patients with renal failure.
- To highlight a previously undocumented adverse reaction to lanthanum therapy.
Main Methods:
- Case report of two patients (one male, one female) on renal replacement therapy.
- Patients were undergoing peritoneal dialysis (PD) and hemodialysis (HD).
- Monitoring of liver function tests in patients receiving lanthanum.
Main Results:
- Lanthanum administration was associated with abnormal liver function tests in both patients.
- This represents a novel adverse effect of lanthanum not previously documented.
- The patients' ages were 70 years (male, PD) and 44 years (female, HD).
Conclusions:
- Lanthanum may cause abnormal liver function tests, a previously unreported adverse reaction.
- Healthcare providers should monitor liver function in patients on lanthanum therapy, especially those with renal failure.
- Further research is needed to understand the mechanism and prevalence of this adverse effect.
Related Concept Videos
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
01:24Hemodialysis II: Procedure and Complications
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
01:26Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
01:25Hemodialysis III: Nursing Management
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this measurement...
01:24Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
01:28Esophageal Varices-II: Clinical Features and Management
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...