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Related Experiment Video

Updated: Jun 17, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Immature dengue virus: a veiled pathogen?

Izabela A Rodenhuis-Zybert¹, Hilde M van der Schaar, Júlia M da Silva Voorham

¹Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.

|January 12, 2010

Summary

This summary is machine-generated.

Immature dengue virus particles become infectious when they interact with prM antibodies, potentially contributing to severe dengue disease during secondary infections. This interaction enhances cell entry and infectivity.

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Area of Science:

Virology
Immunology
Infectious Diseases

Background:

Dengue virus-infected cells release immature virions containing prM proteins.
Elevated prM antibody levels are observed in infected individuals, particularly during secondary infections.
Immature dengue virus particles are generally considered non-infectious.

Purpose of the Study:

To investigate the role of prM antibodies in the infectivity of immature dengue virus particles.
To elucidate the mechanisms by which immature dengue virus contributes to disease pathogenesis.

Main Methods:

Assessing the infectivity of immature dengue virus particles after interaction with prM antibodies.
Analyzing the role of Fc-receptor-expressing cells in immature virion entry.
Investigating the necessity of furin enzymatic activity for viral maturation and infectivity.

Main Results:

Fully immature dengue virus particles gain significant infectivity upon binding with prM antibodies.
prM antibodies facilitate the efficient entry of immature virions into Fc-receptor-expressing cells.
Furin enzymatic activity is crucial for processing internalized immature virions into infectious forms.

Conclusions:

Immature dengue virus particles can become highly infectious in the presence of prM antibodies.
This mechanism may contribute to severe dengue pathogenesis, especially during secondary infections or in specific primary infection scenarios.
Understanding this pathway offers insights into dengue disease progression and potential therapeutic targets.