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Updated: Jun 17, 2026

Development and Application of Rapamycin-regulated Tyrosine Phosphatases
Published on: September 6, 2024
Chemical rescue of protein tyrosine phosphatase activity
Vincent L Chen1, Anthony C Bishop
1Amherst College, Department of Chemistry, Amherst, MA, USA.
Abstract:
We report that the activity of a rationally engineered protein tyrosine phosphatase (PTP) mutant can be fully rescued by the addition of the biarsenical fluorescein derivative FlAsH, a compound that does not affect the activity of wild-type PTPs.
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