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Chemical rescue of protein tyrosine phosphatase activity

Vincent L Chen1, Anthony C Bishop

  • 1Amherst College, Department of Chemistry, Amherst, MA, USA.

Chemical Communications (Cambridge, England)
|January 12, 2010
PubMed

Abstract:

We report that the activity of a rationally engineered protein tyrosine phosphatase (PTP) mutant can be fully rescued by the addition of the biarsenical fluorescein derivative FlAsH, a compound that does not affect the activity of wild-type PTPs.

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