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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

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Updated: Jun 17, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Application of platelet function testing to the bedside.

Craig D Williams1, Ganesh Cherala, Victor Serebruany

  • 1Department of Pharmacy Practice, OSU/OHSU College of Pharmacy, 3303 SW Bond Ave., CH12C Portland, Oregon, USA. williacr@ohsu.edu

Thrombosis and Haemostasis
|January 12, 2010
PubMed
Summary
This summary is machine-generated.

Bedside platelet function testing aids anti-platelet drug decisions but faces implementation barriers. Platelet aggregometry needs more research for routine clinical use in guiding therapy.

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Last Updated: Jun 17, 2026

Microfluidics in Assessing Platelet Function
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Area of Science:

  • Clinical pharmacology
  • Hematology
  • Translational medicine

Background:

  • Platelet reactivity testing is crucial for optimizing anti-platelet therapy.
  • Current implementation of platelet function tests in clinical practice is limited.
  • Research-based assays are not yet widely available for routine clinical use.

Purpose of the Study:

  • To review contemporary issues in bedside platelet testing.
  • To update clinicians on the status of platelet function assays.
  • To identify future clinical research directions in platelet testing.

Main Methods:

  • Literature review of current bedside platelet testing techniques.
  • Analysis of barriers to clinical implementation.
  • Discussion of platelet aggregometry's current status and future needs.

Main Results:

  • Significant barriers hinder the widespread clinical adoption of platelet function tests.
  • Many research-grade tests are not yet clinically applicable.
  • Platelet aggregometry shows promise but requires further validation for routine use.

Conclusions:

  • Bedside platelet testing has potential but requires overcoming implementation hurdles.
  • Further research is essential to establish the clinical utility of platelet aggregometry.
  • Future research should focus on validating bedside tests for guiding anti-platelet therapy.