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Updated: Jun 17, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

[Inflammatory myofibroblastic tumor].

I Leuschner¹

¹Kindertumorregister der Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH), Sektion Kinderpathologie, Institut für Pathologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Michaelisstr. 11, 24105 Kiel.

|January 12, 2010

Summary

This summary is machine-generated.

Inflammatory myofibroblastic tumors (IMT) are soft tissue lesions often found in the abdomen. While typically benign, about one-third of abdominal IMTs recur, and malignant cases are rare.

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Isolation of Primary Myofibroblasts from Mouse and Human Colon Tissue

Isolation of Primary Myofibroblasts from Mouse and Human Colon Tissue

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Isolation of Primary Myofibroblasts from Mouse and Human Colon Tissue

Isolation of Primary Myofibroblasts from Mouse and Human Colon Tissue

Published on: October 12, 2013

Area of Science:

Oncology
Pathology
Soft Tissue Neoplasms

Background:

Inflammatory myofibroblastic tumor (IMT) is a rare soft tissue neoplasm.
IMTs exhibit a spindle cell morphology with significant inflammatory cell infiltration, primarily plasma cells.
These tumors can arise in virtually any body site, with a predilection for the abdomen.

Purpose of the Study:

To characterize the key features of inflammatory myofibroblastic tumors.
To investigate the diagnostic utility of immunohistochemistry in identifying myofibroblastic differentiation.
To assess the clinical behavior, including recurrence rates and malignant potential, of IMTs, particularly in abdominal cases.

Main Methods:

Histopathological examination of tumor samples.
Immunohistochemical staining to demonstrate myofibroblastic differentiation.
Analysis of clinical data regarding tumor location, treatment, and outcomes.

Main Results:

IMTs are characterized by spindle cells and a prominent inflammatory infiltrate, predominantly plasma cells.
Immunohistochemistry confirms myofibroblastic differentiation.
Anaplastic lymphoma kinase (ALK) expression is detected in approximately 50% of IMTs.
While generally benign, approximately one-third of abdominal IMTs are associated with recurrence.
Malignant presentations of IMT are infrequent.

Conclusions:

Inflammatory myofibroblastic tumors are identifiable by their distinct histological and immunohistochemical features.
Abdominal IMTs have a notable recurrence rate, necessitating careful follow-up.
The overall prognosis for IMT is favorable, with rare instances of malignancy.