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Updated: Jun 17, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
[Inflammatory myofibroblastic tumor]
1Kindertumorregister der Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH), Sektion Kinderpathologie, Institut für Pathologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Michaelisstr. 11, 24105 Kiel.
Abstract:
Inflammatory myofibroblastic tumor (IMT) is a soft tissue lesion which can be found in almost all parts of the human body, but shows the highest incidence in the abdomen. It is a spindle cell lesion with prominent inflammatory infiltrate which consists predominantly of plasma cells. Using immunohistochemistry a myofibroblastic differentiation can be demonstrated. ALK is expressed in approximately 50% of tumors. The tumors are associated with a benign behavior but recurrences occur in about one third of abdominal cases. Malignant cases are rare.
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