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Related Experiment Video

Updated: Jun 17, 2026

Mouse Fetal Whole Intestine Culture System for Ex Vivo Manipulation of Signaling Pathways and Three-dimensional Live Imaging of Villus Development
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Ror2 is required for midgut elongation during mouse development.

Makiko Yamada1, Jun Udagawa, Akihiro Matsumoto

  • 1Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan. makiyamd@med.shimane-u.ac.jp

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|January 12, 2010
PubMed
Summary

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The receptor tyrosine kinase Ror2 is crucial for midgut elongation in mouse embryos. Its absence leads to shorter midguts by affecting epithelial cell behavior through convergent extension.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Receptor tyrosine kinase Ror2 mediates noncanonical Wnt signaling and is vital for morphogenesis.
  • Ror2 plays roles in various embryonic organs, but its function in the developing gut is largely unknown.
  • Wnt5a is present in the developing gut and its absence causes abnormal phenotypes.

Purpose of the Study:

  • To investigate the expression pattern and roles of Ror2 in the developing mouse gut.
  • To elucidate the mechanism by which Ror2 influences gut development.

Main Methods:

  • Analysis of Ror2 expression in mouse embryos from E10.5 to E12.5.
  • Phenotypic analysis of Ror2-/- embryos at E11.5, focusing on midgut morphology and cell distribution.

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Last Updated: Jun 17, 2026

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Main Results:

  • Ror2 showed strong, differential expression in the rostral and middle midgut endoderm.
  • Ror2-/- embryos displayed a shorter middle midgut with increased epithelial cell accumulation and larger diameter.
  • Total cell numbers in the middle midgut remained unchanged in Ror2-/- embryos.

Conclusions:

  • Ror2 is essential for normal midgut elongation during mouse embryogenesis.
  • Ror2 likely regulates midgut elongation via an epithelial convergent extension mechanism.
  • These findings highlight a novel role for Ror2 in gut development.