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Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
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Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with a...
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Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
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Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
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Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
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Related Experiment Video

Updated: Jun 17, 2026

A Conflict Model of Reward-seeking Behavior in Male Rats
06:11

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Published on: February 20, 2019

Addiction concepts and international control.

Robin Room1

  • 1Stockholm Univ., and Deputy Director of the Centre for Social Research on Alcohol and Drugs.

The Social History of Alcohol and Drugs
|January 13, 2010
PubMed
Summary
This summary is machine-generated.

Addiction concepts emerged with increased psychoactive substance availability during global expansion. These concepts helped reconcile substance accessibility with societal demands for sobriety, influencing early alcohol and drug policies.

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Area of Science:

  • Social Sciences
  • History of Medicine
  • Criminology

Background:

  • The rise of addiction as a concept is linked to the expansion of psychoactive substance availability during European empires and the Industrial Revolution.
  • Addiction concepts emerged as a framework to understand the tension between increased substance access and the need for sobriety in new industrial societies.

Observation:

  • The concept of addiction was initially applied to alcohol and subsequently extended to other psychoactive substances.
  • The historical development of addiction concepts reflects societal responses to changing patterns of substance use and availability.

Findings:

  • Addiction concepts served to explain contradictions between substance availability and societal demands for sobriety.
  • The definition and application of addiction concepts evolved over time, broadening from alcohol to other substances.

Implications:

  • The historical context of addiction concepts is crucial for understanding their current application and limitations.
  • The study highlights the complex and often contradictory role of addiction in international drug control treaties, where it is cited as justification but often excluded from practical considerations.