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Response variability is associated with self-reported cognitive fatigue in multiple sclerosis.

Jared M Bruce1, Amanda S Bruce, Peter A Arnett

  • 1Department of Psychology, University of Missouri-Kansas City, 5100 Rockhill Road, Kansas City, MO 64110, USA. Brucejm@umkc.edu

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Cognitive fatigue in multiple sclerosis (MS) is linked to response time variability (RTV). This study found higher RTV in MS patients, correlating with their self-reported cognitive fatigue, suggesting RTV as a key measure.

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Area of Science:

  • Neuroscience
  • Clinical Psychology
  • Neurology

Background:

  • Cognitive fatigue is a prevalent and disabling symptom in multiple sclerosis (MS).
  • Existing research shows a disconnect between subjective fatigue reports and objective neuropsychological tests in MS patients.
  • The precise relationship between cognitive fatigue and measurable cognitive deficits in MS requires further investigation.

Purpose of the Study:

  • To investigate the association between self-reported cognitive fatigue and response time variability (RTV) in individuals with MS.
  • To determine if RTV can serve as a more sensitive indicator of cognitive dysfunction related to fatigue in MS.

Main Methods:

  • Participants included patients with relapsing-remitting and secondary progressive MS, alongside a control group.
  • Response time variability (RTV) was measured as an objective indicator of cognitive performance.
  • Self-reported levels of cognitive fatigue were collected from all participants.

Main Results:

  • Multiple sclerosis patients exhibited significantly elevated RTV compared to healthy controls.
  • A strong positive correlation was observed between RTV and self-reported cognitive fatigue in MS patients.
  • This correlation was particularly notable in both relapsing-remitting and secondary progressive MS subtypes.

Conclusions:

  • Response time variability (RTV) emerges as a promising objective measure associated with cognitive fatigue in multiple sclerosis.
  • Findings suggest that RTV may offer a more nuanced understanding of cognitive challenges faced by MS patients than traditional neuropsychological tests.
  • Further research employing advanced methodologies is recommended to fully understand the complex interplay between cognitive fatigue and neuropsychological functioning in MS.