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Updated: Jun 17, 2026

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
Published on: November 19, 2014
Semantic ambiguity resolution in positive schizotypy: a right hemisphere interpretation
Gina M Grimshaw1, Frances M Bryson, Ruth Ann Atchley
1School of Psychology, Victoria University of Wellington, Wellington, New Zealand. gina.grimshaw@vuw.ac.nz
Individuals high in schizotypy show impaired inhibition of subordinate word meanings, unlike those low in schizotypy. This difference in semantic processing may reflect altered right hemisphere activation in schizotypy.
Area of Science:
- Cognitive Neuroscience
- Psycholinguistics
- Clinical Psychology
Background:
- Positive schizotypal traits are linked to right hemisphere brain activity.
- Hemispheric differences exist in processing semantic ambiguity: left hemisphere favors dominant meanings, right hemisphere accesses both.
Purpose of the Study:
- To investigate if positive schizotypy influences semantic ambiguity processing, reflecting hemispheric activation differences.
- To examine priming patterns in individuals with varying levels of positive schizotypy.
Main Methods:
- A semantic ambiguity task was administered to assess priming effects.
- Participants were categorized based on their levels of positive schizotypy.
Main Results:
- Individuals low in schizotypy inhibited subordinate meanings as expected.
- Individuals high in schizotypy primed dominant meanings but failed to inhibit subordinate meanings.
Conclusions:
- Failure to inhibit subordinate meanings in high schizotypy may contribute to thought disorder.
- Altered semantic processing and hemispheric function are implicated in schizotypal traits.
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