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Awareness of glucose-6 phosphate-dehydrogenase deficiency in celiac disease

F O Hosnut1, O Canan1, F Özcay1

  • 1Department of Pediatric Gastroenterology, Hepatology and Nutrition, Başkent University Faculty of Medicine, Ankara, TurkeyObstetric and Children Hospital, Adana, TurkeyDepartment of Pediatric Hematology, Başkent University Faculty of Medicine, Ankara, Turkey.

Acta Paediatrica (Oslo, Norway : 1992)
|January 13, 2010
PubMed

Insights

Individuals with celiac disease (CD) may require vitamin K for bleeding issues. However, vitamin K can cause red blood cell breakdown in those with glucose-6-phosphate dehydrogenase deficiency.

Area of Science:

  • Gastroenterology and Hematology
  • Nutritional Deficiencies

Background:

  • Celiac disease (CD) is linked to various hematological issues, including anemia and coagulopathy.
  • Vitamin K deficiency can impair blood clotting, necessitating correction before procedures like endoscopic biopsy in suspected CD patients.

Observation:

  • Vitamin K administration is crucial for correcting coagulopathy in celiac disease patients.
  • Vitamin K can induce hemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Findings:

  • Coagulopathy in celiac disease patients often requires vitamin K intervention.
  • A critical interaction exists between vitamin K therapy and G6PD deficiency, posing a risk of hemolysis.

Implications:

  • Clinicians must consider G6PD deficiency when administering vitamin K to celiac disease patients.
  • Screening for G6PD deficiency is advisable in celiac disease patients requiring vitamin K therapy to prevent adverse events.
Abstract

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