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In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
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Related Experiment Video

Updated: Feb 13, 2026

Determination of Tripartite Interaction between Two Monomers of a MADS-box Transcription Factor and a Calcium Sensor Protein by BiFC-FRET-FLIM Assay
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Molecules of madness.

Solomon H Snyder1

  • 1The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ssnyder@jhmi.edu

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|January 13, 2010
PubMed
Summary
This summary is machine-generated.

This narrative explores a five-decade scientific journey from psychiatry to neurochemistry. It offers insights for young scientists navigating diverse research interests in neuroscience and pharmacology.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Biochemistry

Background:

  • The author's career path evolved from an initial interest in psychiatry and the human mind.
  • This trajectory led to in-depth biochemical investigations of neurotransmitters and pharmacological agents.

Discussion:

  • The narrative highlights the value of interdisciplinary exploration in scientific careers.
  • It emphasizes the potential benefits of pursuing "quirky" or "impatient" curiosity across multiple research domains.

Key Insights:

  • A diverse scientific background can foster unique perspectives and problem-solving approaches.
  • Early career scientists can draw inspiration from unconventional paths in research.

Outlook:

  • Encouraging broad scientific curiosity can lead to novel discoveries in fields like neuroscience and drug development.
  • Sharing personal scientific journeys can guide and motivate the next generation of researchers.