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Kickstarting Foxp3 with c-Rel

Chyi-Song Hsieh1

  • 1Department of Internal Medicine, Division of Rheumatology, Washington University, Saint Louis, MO 63110, USA.

Immunity
|January 13, 2010
PubMed

In this issue of Immunity, reports by Long et al. (2009) and Ruan et al. (2009) suggest that the transcription factor NF-kappaB-c-Rel is an important molecular mechanism by which T cell receptor-specificity for self-antigens instructs the selection of Foxp3(+) regulatory T cells.

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