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Related Experiment Video

Updated: Jun 17, 2026

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19
06:29

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19

Published on: May 25, 2022

Minimal clinically important difference for the ocular surface disease index.

Kimberly L Miller1, John G Walt, David R Mink

  • 1ICON Clinical Research, 188 Embarcadero, Ste 200, San Francisco, CA 94105, USA. Kimberly.Miller@iconplc.com

Archives of Ophthalmology (Chicago, Ill. : 1960)
|January 13, 2010
PubMed
Summary

The minimal clinically important difference (MCID) for the Ocular Surface Disease Index (OSDI) in dry eye disease was estimated using observational data. These findings aid in interpreting OSDI score changes for clinicians and researchers.

Related Experiment Videos

Last Updated: Jun 17, 2026

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19
06:29

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19

Published on: May 25, 2022

Area of Science:

  • Ophthalmology
  • Clinical Research
  • Patient-Reported Outcomes

Background:

  • Dry eye disease significantly impacts patients' quality of life.
  • The Ocular Surface Disease Index (OSDI) is a key patient-reported outcome measure for dry eye.
  • Establishing the minimal clinically important difference (MCID) for the OSDI is crucial for interpreting treatment efficacy.

Purpose of the Study:

  • To determine the MCID for the OSDI questionnaire in quantifying dry eye disease severity.
  • To provide benchmarks for meaningful change in OSDI scores.

Main Methods:

  • Data from the Restasis Review of Efficacy and Safety vs Tears in the Relief of Dry Eye (RESTORE) registry were analyzed.
  • Clinician Global Impression (CGI) and Subject Global Assessment (SGA) were used as anchors to estimate MCID.
  • OSDI scores were categorized into normal, mild, moderate, and severe dry eye disease.

Main Results:

  • The study included 310 patients (81.6% female, mean age 57.8 years).
  • MCID estimates for the overall OSDI score ranged from 7.0 to 9.9.
  • Specific MCID ranges varied based on disease severity: 4.5–7.3 for mild/moderate and 7.3–13.4 for severe dry eye.

Conclusions:

  • Observational data provided estimates for MCIDs across different baseline OSDI categories of dry eye disease.
  • These MCID values will help clinicians and researchers interpret changes in OSDI scores more effectively.
  • This research contributes to a better understanding of clinically meaningful improvements in dry eye management.