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Knee Arthrocentesis in Adults
Published on: February 25, 2022
Thrombosis markers in hip versus knee arthroplasty: a pilot study
Olav Reikeras1, Torkil Clementsen
1Department of Orthopaedics, Rikshospitalet University Clinic, University of Oslo, Norway. olav.reikeras@rikshospitalet.no
Journal of Orthopaedic Surgery (Hong Kong)
|January 13, 2010
Summary
Thrombosis markers indicate systemic thrombin generation begins during hip arthroplasty and after tourniquet removal in knee arthroplasty. This suggests wound blood activation is key for these thrombosis markers.
Area of Science:
- Orthopedic Surgery
- Thrombosis Research
- Biomarker Analysis
Background:
- Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are common orthopedic procedures.
- Understanding perioperative thrombosis risk is crucial for patient safety.
Purpose of the Study:
- To compare thrombosis and fibrinolysis markers in patients undergoing THA versus TKA.
- Investigate the timing and extent of thrombin generation in these procedures.
Main Methods:
- A comparative study of 7 women undergoing THA and 7 women undergoing TKA.
- Blood samples analyzed for prothrombin fragment 1.2 (F1.2), plasmin/alpha2-antiplasmin complex (PAP), and D-dimer at three time points.
- Patients received standard thromboprophylaxis; TKA patients used a pneumatic tourniquet.
Main Results:
- F1.2 and D-dimer levels increased earlier (at wound closure) in the THA group compared to the TKA group (4 hours post-surgery).
- PAP levels remained stable in THA but increased significantly post-surgery in TKA.
- These findings suggest differential timing of systemic thrombin generation based on surgical site and tourniquet use.
Conclusions:
- Systemic thrombin generation initiates perioperatively in THA and post-tourniquet deflation in TKA.
- The results highlight the importance of wound blood circulation in activating thrombosis mediators.
