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Updated: Jun 17, 2026
08:49
Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
Published on: May 11, 2018
Emerging ventricular assist devices for long-term cardiac support.
Rajan Krishnamani1, David DeNofrio, Marvin A Konstam
1The Cardiovascular Center, Tufts Medical Center, Boston, MA 02111, USA.
Nature Reviews. Cardiology
|January 13, 2010
Summary
Ventricular assist devices (VADs) offer an alternative for advanced heart failure patients. Newer VADs show promise for long-term support, expanding treatment options beyond transplantation.
Area of Science:
- Cardiology
- Biomedical Engineering
Background:
- Heart failure remains a significant cause of death despite treatment advances.
- Declining donor heart availability necessitates alternative therapies.
- Ventricular assist devices (VADs) are evolving as a crucial treatment option.
Purpose of the Study:
- To review third-generation ventricular assist devices (VADs) for mechanical cardiac support.
- To explore the expanding role of VADs as destination therapy for advanced heart failure.
Main Methods:
- Review of current literature on third-generation VAD technology.
- Analysis of clinical investigations and development stages of new VADs.
Main Results:
- Innovations in VAD technology improve mechanical reliability and patient outcomes.
- VADs are increasingly used for long-term destination therapy, not just as a bridge to transplant.
Conclusions:
- Third-generation VADs represent a significant advancement in managing advanced heart failure.
- These devices are poised to become a vital component of heart failure treatment, potentially broadening patient eligibility.
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