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Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD

Lin Teng1, Jian Zhao, Feifei Wang

  • 1Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Cell Research
|January 13, 2010
PubMed

Keywords:
Alzheimer's disease mechanismsecretase regulationGPCR signalingamyloid-beta production

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