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Published on: February 10, 2023
Tuberculosis and Venous Thromboembolism: a case series
Ivone M Goncalves1, Daniela Costa Alves, Aurora Carvalho
1Pneumology Department, Vila Nova de Gaia/Espinho Hospital Centre, Porto, Portugal.
Tuberculosis (TB) can lead to rare but life-threatening blood clots like deep venous thrombosis and pulmonary embolism. Early recognition and treatment are crucial for better outcomes in TB patients experiencing these complications.
Area of Science:
- Infectious Diseases
- Hematology
- Pulmonology
Background:
- Tuberculosis (TB) is a prevalent global infectious disease and a significant public health concern.
- Venous thromboembolism (VTE), though rare, is a serious complication of TB that can be fatal.
Purpose of the Study:
- To report two cases of severe pulmonary tuberculosis associated with venous thromboembolism.
- To highlight the unusual presentation of VTE in one TB case and its later development in another.
Main Methods:
- Case series presentation of two adult male patients with severe pulmonary tuberculosis.
- Clinical case reporting and review of associated thromboembolic events.
Main Results:
- One patient presented with a thromboembolic event as an unusual initial manifestation of TB.
- The second patient developed deep venous thrombosis later in the course of his TB disease.
Conclusions:
- An association exists between TB-induced inflammation and a hypercoagulable state.
- Physicians should consider VTE in TB patients, especially early in treatment, for prompt diagnosis and management.
- Awareness of VTE risk in TB is vital to prevent potentially fatal outcomes.
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