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Social phobia following maprotiline: the first case report
Seyed Hamzeh Hosseini1, Ebrahim Salehifar
1Department of Psychiatry, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.
Cases Journal
|January 13, 2010
Summary
Maprotiline, a medication for depression, may unexpectedly cause social phobia in some patients. This case report highlights a potential adverse drug reaction, suggesting further research into antidepressant-induced anxiety is needed.
Area of Science:
- Psychiatry
- Pharmacology
Background:
- Anxiety symptoms can arise from medications or substance abuse.
- Adverse drug reactions (ADRs) are a known cause of psychiatric symptoms.
- Social phobia is a specific anxiety disorder with significant impact.
Purpose of the Study:
- To report a novel case of social phobia as an adverse drug reaction to maprotiline.
- To contribute to the understanding of antidepressant-induced psychiatric side effects.
Main Methods:
- Case presentation of a 27-year-old male with dysthymia.
- Review of patient's treatment history including TCAs, SSRIs, MAOIs, liothyronine, and lithium.
- Administration of maprotiline (50 mg daily) and observation of subsequent symptoms.
Main Results:
- Maprotiline improved the patient's dysthymia symptoms.
- The patient developed new-onset social phobia after initiating maprotiline therapy.
- This represents a previously unreported adverse drug reaction to maprotiline.
Conclusions:
- Maprotiline may precipitate social phobia in susceptible individuals.
- Further research is required to elucidate the mechanism and prevalence of this ADR.
- Clinicians should be aware of the potential for maprotiline to induce social phobia.
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