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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Reactions02:06

Allergic Reactions

Overview

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Related Experiment Video

Updated: Jun 17, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Urticaria and infections.

Bettina Wedi1, Ulrike Raap, Dorothea Wieczorek

  • 1Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany. wedi.bettina@mh-hannover.de

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
|January 13, 2010
PubMed
Summary
This summary is machine-generated.

Infections, particularly Helicobacter pylori, are strongly linked to spontaneous urticaria. Treating these infections can significantly improve chronic urticaria symptoms.

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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

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Last Updated: Jun 17, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Immunology

Background:

  • Urticaria encompasses diverse conditions with a common skin manifestation.
  • The precise role of infections in mast cell activation and urticaria pathogenesis remains unclear.
  • A causal link between infections and spontaneous acute urticaria is established, with chronic forms originating from acute episodes.

Purpose of the Study:

  • To review the role of infections in various urticaria subtypes.
  • To highlight the significance of diagnosing and treating infections in urticaria management.
  • To update readers on current understanding of infection-induced urticaria.

Main Methods:

  • Review of existing literature on infections and urticaria.
  • Analysis of studies evaluating Helicobacter pylori eradication in chronic urticaria patients.
  • Comparison of outcomes in treated vs. untreated urticaria patients.

Main Results:

  • Strong evidence supports infections as triggers for spontaneous acute urticaria.
  • Successful treatment of persistent infections has led to remission in chronic urticaria.
  • Studies show a statistically significant benefit (p < 0.001) in chronic urticaria following proven Helicobacter pylori eradication.

Conclusions:

  • Infections play a significant role in urticaria, especially spontaneous forms.
  • Screening for and treating infections, such as Helicobacter pylori, should be part of routine urticaria work-up.
  • Effective management of underlying infections offers a therapeutic avenue for chronic urticaria.