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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Regulation of Hematopoietic Stem Cells01:01

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Mesenchymal Stem Cells01:19

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Inflammatory Response01:28

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iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Differentiation of Common Myeloid Progenitor Cells01:15

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Related Experiment Video

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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

Stem cells, inflammation and allergy.

Marie-Renee Blanchet1, Kelly M McNagny

  • 1The Biomedical Research Centre, 2222 Health Sciences Mall, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada. marierenee@brc.ubc.ca

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
|January 13, 2010
PubMed
Summary
This summary is machine-generated.

Early hematopoietic stem cells (HSCs) and progenitor cells are recruited to inflammation sites, potentially worsening allergic diseases. Research reviews evidence and highlights CD34

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Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
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Published on: September 20, 2019

Area of Science:

  • Immunology
  • Stem Cell Biology
  • Allergy Research

Background:

  • Emerging evidence suggests a role for early hematopoietic stem cells (HSCs) and progenitor cells in allergy and inflammation development.
  • These cells, including CD34+ cells, are observed migrating to inflammatory sites in allergic diseases.
  • This migration is thought to utilize similar receptors as those involved in stem cell homing to bone marrow.

Purpose of the Study:

  • To review the evidence supporting the recruitment of hematopoietic stem and progenitor cells to allergic inflammation sites.
  • To discuss the molecular mechanisms, including specific receptors, involved in this recruitment process.
  • To present novel findings on the role of the stem cell antigen CD34 in allergic inflammation.

Main Methods:

  • Literature review of studies investigating stem cell recruitment in allergic inflammation.
  • Analysis of molecular pathways and cell surface markers involved in stem cell migration.
  • Presentation of original research data focusing on CD34's function.

Main Results:

  • Evidence supports the recruitment of hematopoietic stem and progenitor cells, not just mature lineages, to sites of allergic inflammation.
  • Key molecules like PSGL-1, CXCL12, alpha4-beta1 integrin, and CD44 are implicated in this stem cell trafficking.
  • Novel observations indicate a specific role for CD34 in the context of allergic inflammation.

Conclusions:

  • Hematopoietic stem and progenitor cells are recruited to inflammatory sites and may contribute to disease perpetuation.
  • Understanding these mechanisms, particularly the role of CD34, offers potential therapeutic targets for allergic diseases.
  • Further research is warranted to elucidate the precise functions of recruited stem cells in inflammation.