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Related Experiment Video

Updated: Jun 17, 2026

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus (AAV) Capsid Variants

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus (AAV) Capsid Variants

Published on: October 18, 2022

Genome-based approaches to vaccine development.

Marirosa Mora¹, John L Telford

¹Novartis Vaccines, Via Fiorentina 1, 53100 Siena, Italy. john.telford@novartis.com

Journal of Molecular Medicine (Berlin, Germany)

|January 13, 2010

Summary

Advances in bioinformatics and proteomics are revolutionizing vaccinology. Combining computational and experimental methods creates a focused list of antigens, reducing time and cost for new protein vaccines.

Area of Science:

Microbiology
Immunology
Bioinformatics

Background:

The field of vaccinology is rapidly advancing due to the availability of numerous bacterial genome sequences.
Progress in bioinformatics and experimental proteomic tools are key drivers of this revolution.

Purpose of the Study:

To describe a novel strategy for identifying potential vaccine antigens.
To reduce the time and cost associated with developing new protein vaccine formulations.

Main Methods:

Integration of stringent in silico (computational) criteria with experimental approaches.
Prioritization of potential antigens based on combined analytical methods.

Main Results:

A more targeted strategy for antigen identification has been developed.

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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

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Published on: January 7, 2019

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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

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Published on: January 7, 2019

The approach allows for the creation of a restricted and prioritized list of antigens.

Conclusions:

The combined computational and experimental strategy accelerates the identification of vaccine candidates.
This approach optimizes the development pipeline for novel protein vaccines.