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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
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Related Experiment Video

Updated: Jun 17, 2026

Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine
09:25

Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine

Published on: May 21, 2012

Gatekeepers of intestinal inflammation.

Heather A Arnett1, Joanne L Viney

  • 1Inflammation Research, Amgen, Seattle, WA 98119, USA. harnett@amgen.com

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|January 13, 2010
PubMed
Summary

The intestine maintains balance despite constant challenges from food and microbes. This review explores regulatory pathways that control gut inflammation and may be disrupted in inflammatory bowel diseases like ulcerative colitis and Crohn's disease.

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Last Updated: Jun 17, 2026

Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine
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Area of Science:

  • Gastroenterology and immunology, focusing on intestinal homeostasis.

Background:

  • The intestinal lining constantly faces antigens from food, bacteria, and pathogens.
  • Maintaining immune tolerance and gut homeostasis is crucial despite this antigenic load.
  • Existing knowledge on precise regulatory mechanisms for gut homeostasis remains incomplete.

Purpose of the Study:

  • To review proposed pathways involved in regulating intestinal inflammation.
  • To examine mechanisms that maintain gut homeostatic balance.
  • To explore how these regulatory pathways are disrupted in ulcerative colitis and Crohn's disease.

Main Methods:

  • Literature review of proposed regulatory pathways in intestinal homeostasis.
  • Analysis of mechanisms involved in dampening inflammatory responses in the gut.
  • Comparative review of pathway function in health versus inflammatory bowel disease.

Main Results:

  • Several pathways are proposed to be critical for controlling gut inflammation.
  • These pathways are essential for maintaining the delicate homeostatic balance in the intestine.
  • Disruptions in these regulatory pathways are implicated in ulcerative colitis and Crohn's disease.

Conclusions:

  • Understanding these regulatory pathways is key to comprehending gut health.
  • Identifying disruptions in these pathways offers insights into inflammatory bowel disease pathogenesis.
  • Further research into these mechanisms may reveal therapeutic targets for ulcerative colitis and Crohn's disease.