Related Experiment Video
Updated: Jun 17, 2026

Optimization of Processing of Tiebangchui with Highland Barley Wine Based on the Box-Behnken Design Combined with the Entropy Method
Published on: May 19, 2023
[Optimization of solubilizing process of Qingkailing injection based on GA-BPNN modeling]
Ruixin Liu1, Nancen Liu, Xinyuan Shi
1School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. liuruixin7@yahoo.com.cn
Objective:
To optimize solubilizing process of Qingkailing injection.
Method:
Uniform design experimental method and GA-BPNN modeling method were applied to optimize the technical parameters, and the solubility of cholic acid in medium was taken as optimizing index.
Result:
The type of solubilizer and pH of medium had greater impact on the index than the concentration for solubilizer. The optimum solubilizer was Tween-80. In a certain range the higher pH of medium was optimum; it was not necessary to use high-concentration solubilizer although there was positive correlation between the index and the concentration of solubilizer.
Conclusion:
Uniform design combined with GA-BPNN modeling method is suitable for optimization of solubilizing process of Chinese materia medica injection, which has certain practical application value.
More Related Videos
08:44Elucidation of the Material Basis of Yiqi Qingjie Formula Against IgA Nephropathy Using UHPLC-Q-Orbitrap HRMS Integrated with Network Pharmacology
Published on: May 19, 2026
13:54A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)
Published on: August 18, 2023
Related Concept Videos
One-Compartment Open Model for IV Bolus Administration: General Considerations
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant, half-life,...
Physiological Pharmacokinetic Models: Assumption with Protein Binding
Two-Compartment Open Model: IV Bolus Administration
The disparity between drug input and the sum of drug transfer rates between...
One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution
Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection
Following the administration of a single intravenous (IV) bolus injection, we can determine the concentration of the drug in the plasma at any given time. This calculation is achieved using a specific equation that integrates the values of Vmax and KM.
We can also...
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...