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Measurement of Heme Synthesis Levels in Mammalian Cells
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[Hemoglobins: diversity of structures and functions]

O V Kosmachevskaia, A F Topunov

    Prikladnaia Biokhimiia I Mikrobiologiia
    |January 14, 2010
    PubMed

    This review briefs the modem concepts of the diversity of hemoglobin functions. The hemoglobins discovered in the representatives of all kingdoms of living nature are described. Specific structural features of various groups of these proteins, including flavohemoglobins and truncated hemoglobins, are discussed. The transport, catalytic, and sensory functions of these proteins are described as well as their roles in oxidative, nitrosative, and carbonyl stresses and the changes in their functions caused by modifications of the molecule. The issues of hemoglobin origin and evolution are discussed.

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