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[Retrospective study on CT findings on the sternal bone after bone marrow aspiration procedure in hematological

Hiroshi Fujita1, Shigeko Nishimura, Kazuyuki Oyama

  • 1Department of Transfusion Medicine, Tokyo Metropolitan Bokutoh Hospital.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|January 14, 2010
PubMed

Insights

CT scans reveal sternal bone abnormalities, including fractures and decreased density, in patients with hematological diseases. These sternal findings may indicate osteoporosis and raise safety concerns for bone marrow aspiration.

Area of Science:

  • Radiology
  • Hematology
  • Orthopedics

Background:

  • Bone marrow aspiration is a common procedure for diagnosing hematological diseases.
  • The sternum is a frequent site for bone marrow aspiration.
  • Potential risks associated with sternal bone marrow aspiration are not fully understood.

Purpose of the Study:

  • To evaluate computed tomography (CT) findings of the sternal bone in patients with hematological diseases.
  • To assess the prevalence of sternal abnormalities and their relationship with systemic bone diseases like osteoporosis.
  • To determine the safety implications of sternal bone marrow aspiration based on CT findings.

Main Methods:

  • Retrospective analysis of CT scans of the sternum in 129 patients with hematological diseases.
  • Patients underwent bone marrow aspiration between August 2005 and July 2007.
  • Correlation of sternal CT findings with lumbar spine bone density to assess for osteoporosis.

Main Results:

  • Sternal abnormalities identified included sternal foramen (3 cases) and incomplete fracture (1 case).
  • Irregularity and decreased bone density of the visceral cortical bone were observed in 66 cases (first intercostal space) and 3 cases (third intercostal space).
  • These sternal findings were significantly associated with decreased bone density in the third lumbar spine, suggesting osteoporosis.

Conclusions:

  • The sternum can exhibit various bone pathologies, including sternal foramen, fractures, and osteoporosis.
  • Sternal bone marrow aspiration may carry higher risks than previously assumed due to these potential abnormalities.
  • Further investigation is warranted to refine safety protocols for sternal bone marrow aspiration.

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