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Long-term stability of serum sodium in hemodialysis patients

Aldo J Peixoto1, Nayan Gowda, Chirag R Parikh

  • 1Medical Service, VA Connecticut Healthcare System, West Haven, CT 06516, USA. aldo.peixoto@yale.edu

Blood Purification
|January 14, 2010
PubMed

Insights

Serum sodium levels in hemodialysis (HD) patients are stable over time. This stability suggests pre-dialysis serum sodium can help personalize dialysate sodium prescriptions for better patient management.

Area of Science:

  • Nephrology
  • Clinical Chemistry
  • Internal Medicine

Background:

  • Hemodialysis (HD) patients exhibit a relationship between dialysate-to-plasma sodium gradient, blood pressure, and interdialytic weight gain.
  • Understanding long-term serum sodium variability is crucial for managing HD patients.

Purpose of the Study:

  • To determine the long-term variability of serum sodium levels in patients undergoing chronic hemodialysis.
  • To assess the stability of serum sodium over a 12-month period in a stable HD cohort.

Main Methods:

  • Retrospective cohort analysis of 100 stable chronic HD patients over 12 months.
  • Evaluation of serum sodium and other routine analytes.
  • Calculation of intraindividual coefficients of variation for serum sodium.

Main Results:

  • Intraindividual coefficients of variation for serum sodium were low (pre-HD: 1.6%, post-HD: 1.8%).
  • Overall serum sodium variability was comparable to laboratory assay variability and lower than other analytes (3.1-30.8%).
  • Pre-dialysis serum sodium showed a trend toward hyponatremia (mean 136 ± 0.8 mEq/L).

Conclusions:

  • Serum sodium levels demonstrate stability over time in hemodialysis patients.
  • Pre-dialysis serum sodium can be a valuable parameter for tailoring individual dialysate sodium prescriptions.
Abstract

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