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Increased oxidative stress in patients with pseudoexfoliation syndrome
Tongabay Cumurcu1, Abuzer Gunduz, Huseyin Ozyurt
1Department of Ophthalmology, Gaziosmanpasa University School of Medicine, Tokat, Turkey. tongabay@superonline.com
Purpose:
The objective of this study was to investigate the antioxidant/oxidant status of serum in patients with pseudoexfoliation syndrome (PEX).
Methods:
Forty-seven patients with PEX and 32 healthy controls were included in the study. Serum total antioxidant capacity (TAC) and total oxidant status (TOS) levels were determined by using a novel automated method.
Results:
A significant increase in serum TOS (p < 0.001) and a significant decrease in serum TAC (p < 0.0001) were observed in PEX patients compared to control subjects.
Conclusion:
TAC decreases while the oxidative stress increases in PEX.
