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Updated: Jun 17, 2026

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
A case of primary cutaneous senile EBV-related diffuse large B-cell lymphoma
Blanca Martin1, Sean Whittaker, Stephan Morris
1Department of Dermatopathology and Skin Tumour Unit, St. John's Institute of Dermatology, London, UK. blanca.martin@gstt.nhs.uk
Abstract:
Epstein-Barr virus is known to be associated with the development of lymphomas in immunosuppressed patients. Recently, age-related immune impairment was recognized as a predisposing factor in the development of Epstein-Barr virus-driven lymphoproliferative processes in elderly patients. We describe the case of an otherwise healthy 84-year-old lady who developed a solitary primary cutaneous diffuse B-cell lymphoma on her leg in which the majority of the malignant cells had Epstein barr early RNA (EBER) and late membrane protein-1 expression, with in situ hybridization and immunohistochemistry, respectively.
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