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[Platelet count and clinical profile of anticardiolipin positive leg ulcers]

Thelma Laroka Skare1, Carmen Autralia Paredes Marcondes Ribas, Osvaldo Malafaia

  • 1Programa de Pós-Graduação em Princípios da Cirurgia do Hospital Universitário Evangélico de Curitiba/Faculdade Evangélica do Paraná, Curitiba, PR - BR. tskare@onda.com.br

Revista Do Colegio Brasileiro De Cirurgioes
|January 14, 2010
PubMed

Insights

Anticardiolipin antibodies are more common in patients with leg ulcers. However, factors like ulcer type or platelet count do not predict antibody presence.

Area of Science:

  • Immunology
  • Vascular Medicine
  • Dermatology

Context:

  • Leg ulcers represent a significant clinical challenge with diverse etiologies.
  • Anticardiolipin antibodies (aCL) are associated with thrombotic events and autoimmune conditions.
  • Understanding the prevalence and predictors of aCL in leg ulcer patients is crucial for diagnosis and management.

Purpose:

  • To determine the prevalence of anticardiolipin antibodies (IgG and IgM) in patients presenting with venous, diabetic, and arterial leg ulcers.
  • To investigate whether platelet count, a history of venous thrombosis, obstetrical history, or the presence of livedo reticularis are associated with aCL positivity in this cohort.

Summary:

  • This study found a significantly higher prevalence of anticardiolipin antibodies in patients with leg ulcers (7.2%) compared to controls (1.3%).
  • No significant association was observed between aCL positivity and gender, previous venous thrombosis, history of abortions, or platelet count.
  • The presence of livedo reticularis was noted in only two patients, limiting conclusions regarding its predictive value.

Impact:

  • The findings suggest an increased prevalence of anticardiolipin antibodies in individuals with leg ulcers, highlighting a potential, yet uncharacterized, link.
  • Clinical markers such as ulcer type, platelet count, and thrombotic history are not reliable indicators for identifying aCL positivity in leg ulcer patients.
  • Further research is warranted to elucidate the specific role and implications of anticardiolipin antibodies in the pathogenesis and management of leg ulcers.
Abstract

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