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Related Experiment Video

Updated: Jun 17, 2026

Cerebellar Regional Dissection for Molecular Analysis

Cerebellar Regional Dissection for Molecular Analysis

Published on: December 5, 2020

Spinocerebellar ataxias.

Hélio A G Teive¹

¹Movement Disorders Unit, Neurology Service, Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná, Curitiba PR, Brazil. hagteive@mps.com.br

Arquivos De Neuro-Psiquiatria

|January 14, 2010

Summary

Spinocerebellar ataxias (SCAs) are diverse neurodegenerative disorders. Clinical examination aids in distinguishing SCA types, guiding genetic testing for accurate diagnosis.

Area of Science:

Neurodegenerative diseases
Cerebellar ataxia
Genetics

Background:

Spinocerebellar ataxias (SCAs) are a group of neurodegenerative diseases.
Characterized by progressive cerebellar ataxia.
Associated symptoms include ophthalmoplegia, cognitive dysfunction, and dementia.

Purpose of the Study:

To review the clinical and genetic aspects of major Spinocerebellar ataxia (SCA) types.
Provide an overview of current knowledge on SCA classification and genetics.

Main Methods:

Literature review using PUBMED and OMIM databases.
Focused on clinical and genetic data of Spinocerebellar ataxias (SCAs).

Main Results:

Thirty Spinocerebellar ataxia (SCA) types are identified, with 16 associated genes.

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A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

Published on: May 21, 2010

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Last Updated: Jun 17, 2026

Cerebellar Regional Dissection for Molecular Analysis

Cerebellar Regional Dissection for Molecular Analysis

Published on: December 5, 2020

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

Published on: May 21, 2010

Common types include SCA3 (Machado-Joseph disease), SCA10, SCA7, SCA2, SCA1, and SCA6.

SCAs exhibit significant genotypic and phenotypic heterogeneity.

Conclusions:

Clinical neurological examination is crucial for assessing Spinocerebellar ataxia (SCA) patients.
A clinical algorithm can assist in patient screening before molecular testing.
This approach helps in determining the correct etiology of the disease.