Related Experiment Video
Updated: Jun 17, 2026

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
Published on: June 26, 2019
Multifaceted activity of HIV Vpr/Vpx proteins: the current view of their virological functions
Mikako Fujita1, Masami Otsuka, Masako Nomaguchi
1Research Institute for Drug Discovery, School of Pharmacy, Kumamoto University, Kumamoto 862-0973, Japan.
Abstract:
Primate immunodeficiency viruses encode viral proteins that are uniquely auxiliary to their growth in host cells. Of these accessory proteins, those designated Vpr and Vpx are least well understood with respect to their functions in the viral replication cycle. Moreover, their assigned roles based on the results in published studies remain controversial. This review summarises current knowledge on human immunodeficiency virus (HIV) Vpr/Vpx proteins, and discusses their functional activities during the viral life cycle in macrophages and T lymphocytes, the two major target cells of HIV infection.
Related Concept Videos
Inhibitors of Virion Maturation and Assembly
Size and Structure of Viral Genomes
Inhibitors of Viral Protein Synthesis
Inhibitors Of Virion Release
Retroviruses
Retrovirus Life Cycles

