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Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

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Fetal interlens distance: normal values during pregnancy.

Z Kivilevitch¹, L J Salomon, B Benoit

¹Maccabi Health Services, Women's Medical Center, Ultrasound Unit, Beer Sheva, Israel.

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology

|January 14, 2010

Summary

Interlens distance (ILD) in fetuses strongly correlates with gestational age and fetal growth parameters. This measurement can help assess fetal orbit and eyeball development, aiding in detecting craniofacial abnormalities.

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Area of Science:

Fetal medicine
Medical imaging
Ophthalmology

Background:

Accurate fetal biometry is crucial for monitoring pregnancy.
Interlens distance (ILD) and biorbital diameter (BOD) are key indicators of fetal orbital development.

Purpose of the Study:

Establish normal ranges for fetal interlens distance (ILD) throughout gestation.
Assess the correlation between ILD and fetal growth parameters, including orbital dimensions.

Main Methods:

A cross-sectional study involving 450 normal singleton fetuses from 12 to 37 weeks of gestation.
Measured ILD and biorbital diameter (BOD) using an oblique anterior coronal section.
Analyzed correlations between ILD, gestational age (GA), and other biometric parameters (BPD, HC, FL, AC).

Main Results:

ILD showed a high positive correlation with gestational age (r² = 0.969) and all measured fetal biometric parameters.
The biorbital diameter to interlens distance ratio remained constant throughout pregnancy.
No significant gender-based differences were observed for ILD or GA.

Conclusions:

Fetal ILD measurements correlate closely with eyeball and surrounding bony structure growth.
ILD can be used interchangeably with BOD for assessing fetal orbit and eyeball development.
ILD serves as a valuable complementary tool for detecting craniofacial and nervous system malformations.