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Updated: Jun 17, 2026

VacuSIP, an Improved InEx Method for In Situ Measurement of Particulate and Dissolved Compounds Processed by Active Suspension Feeders
Published on: August 3, 2016
Critical influences of particles, pores, and prefilters in sterilizing filtration
Russell E Madsen1, Theodore H Meltzer
1The Williamsburg Group, LLC, 18907 Lindenhouse Road, Gaithersburg, MD, USA.
Abstract:
Sterilizing filtration process variables can cause unpredictable results and post-filtration integrity test values that are not representative of those obtained during validation of the filtration process. This paper discusses several points to consider in sterilizing filtration designed to assure the validated process is robust and consistently yields a sterile filtrate. These points include pore- and particle-size distributions, the use and choice of prefilters, pore configuration, and the use of redundant (serial) filtration.
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