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Updated: Jun 17, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
[Preparation and characterization of oridonin submicron emulsions]
1Shanghai Hengrui Pharmaceuticals Co. Ltd., Shanghai, China. yul@shhrp.com
Objective:
To prepare the oridonin submicron emulsion and characterize their properties.
Method:
High pressure homogenization method was employed to prepare the oridonin submicron emulsion and such properties as size, Zeta potential and viscosity were characterized.
Result:
The results showed that the submicron emulsions was formed with the drug loading 1 g L(-1), particle size of (138.87 +/- 0.60) nm, zeta potential of (47.27 +/- 2.31) mV, pH value of (6.02 +/- 0.03) and viscosity of (1.78 +/- 0.015) MPa s, respectively.
Conclusion:
The method is feasible and the submicron emulsions has stable properties. Experiments offer a new formulation of oridonin for clinical application.
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