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Updated: Jun 17, 2026

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen
Published on: January 26, 2024
[Dengue shock syndrome]
J Docquir1, D Tuerlinckx, E Bodart
1Service de Pédiatrie, Cliniques Universitaires UCL de Mont Godinne, 5530 Yvoir.
Insights
Dengue fever, a significant global health issue, can present with prolonged fever. Early diagnosis and treatment are crucial, especially for severe cases, to prevent fatal outcomes.
Area of Science:
- Pediatrics
- Infectious Diseases
- Tropical Medicine
Background:
- Dengue fever is a growing global health concern, often underdiagnosed in non-endemic regions.
- Prophylactic measures for dengue fever have seen limited success worldwide.
- The disease presents a significant challenge due to its potential for severe manifestations.
Observation:
- A 21-month-old child presented with fever of unknown origin following travel to St. Domingue.
- Diagnostic investigations confirmed the presence of Dengue Fever.
- The rarity of the condition in the local region contributed to initial diagnostic uncertainty.
Findings:
- Dengue fever, while often self-limiting, can progress to severe forms.
- Severe dengue fever is associated with substantial mortality and morbidity.
- Delayed diagnosis and treatment significantly increase the risk of fatal outcomes.
Implications:
- Highlights the importance of considering dengue fever in pediatric patients with unexplained fever, especially after travel to endemic areas.
- Underscores the need for increased awareness and improved diagnostic capabilities for dengue fever in non-endemic regions.
- Emphasizes the critical role of prompt medical intervention in managing severe dengue fever cases to improve patient prognosis.
Abstract:
Célia, 21 month-old child, presented to our pediatric clinic a few months ago with a fever of unknown origin after a stay in St-Domingue with her parents. Complementary investigations led to a diagnosis of Dengue Fever. The condition, not very frequent and thus not well known in our countries, represents a major world health problem especially because of the global failure of prophylactic measures. If the disease is self-limited in most cases, severe form can occur, with significant mortality and morbidity. Delay in diagnosis and treatment of these severe cases is often fatal.
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