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Published on: July 24, 2013
Trends in nephropathy among HIV-infected patients
Susan E Buskin1, Mauro S Torno, Deborah F Talkington
1HIV/AIDS Program, Prevention Division, Public Health-Seattle and King County, Seattle, Washington, USA. susan.buskin@kingcounty.gov
Background:
Nephropathy complicates the course and adversely impacts on the prognosis of HIV-infected patients. We examined trends and correlates of all-cause nephropathy (ACN).
Methods:
Correlates of and trends in ACN were examined in the entire Adult/Adolescent Spectrum of HIV Disease longitudinal observational cohort. Patients were enrolled and followed in the cohort for a median period of 3 years between January 1990 and December 2003 in 11 US metropolitan areas.
Results:
The incidence of ACN rose among HIV-infected individuals through the mid-1990s, then declined. The proportion of patients with ACN at the time of death increased over the study period. Black race, injection-drug use (IDU), indinavir, hypertension, diabetes, decreased CD4+ lymphocyte count, increased viral load, and increased age were all highly associated with ACN.
Discussion:
Nephropathy represents an important health disparity impacting HIV-infected blacks and IDU with implications for mortality.
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