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Related Experiment Video

Updated: Jun 17, 2026

Reactive Vapor Deposition of Conjugated Polymer Films on Arbitrary Substrates

Reactive Vapor Deposition of Conjugated Polymer Films on Arbitrary Substrates

Published on: January 17, 2018

Controlled release multiple layer coatings.

Dakshinamurthy Devanga-Chinta¹, Richard A Graves, Sarala Pamujula

¹Center for Nanomedicine and Drug Delivery, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125-1098, USA.

Drug Development and Industrial Pharmacy

|January 15, 2010

Summary

This summary is machine-generated.

This study introduces a computer-controlled multi-layer coating process for drug-loaded beads using syringe pumps. Changing the sequence of drug and polymer layers significantly alters drug release profiles.

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Area of Science:

Pharmaceutical Technology
Materials Science

Background:

Traditional fluid-bed coating relies on manual peristaltic pumps for single-layer application.
Precise control over multi-layer coating parameters is challenging with existing methods.

Purpose of the Study:

To develop and evaluate a computer-controlled system for consecutive spraying of multiple coating solutions.
To enable the formation of multi-layered coatings on drug-loaded beads with enhanced control.

Main Methods:

Utilized a fluid-bed coating machine equipped with computer-controlled syringe pumps.
Prepared nine types of controlled-release beads using ethylcellulose and chitosan solutions.
Investigated the impact of varying spray rates and polymer solution volumes on coating characteristics.

Main Results:

Altering ethylcellulose concentration in the solvent significantly increased lag time.
Multi-layer coating with sequential drug and polymer application drastically reduced lag time and accelerated drug release.
Dissolution profiles were significantly modified by changing the order of drug and polymer layers.

Conclusions:

The developed computer-controlled multi-layer coating process offers precise control over drug release.
Sequential layering of drug and polymer solutions is a critical factor in modulating drug release kinetics.
This method provides a novel approach for designing advanced controlled-release drug delivery systems.