Related Experiment Video

Updated: Jun 17, 2026

Development of Recombinant Proteins to Treat Chronic Pain
10:37

Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018

Insight into pain-inducing and -related gene expression: a challenge for development of novel targeted therapeutic

Ioanna Vasileiou1, Constantinos Giaginis, Chris Klonaris

  • 1Department of Forensic Medicine & Toxicology, Medical School, National & Kapodistrian University of Athens, Athens, Greece.

Fundamental & Clinical Pharmacology
|January 15, 2010
PubMed

Insights

Genomic and proteomic research is identifying new pain targets. These molecular insights could lead to more effective, individualized pain treatments for patients unresponsive to current therapies.

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Pain management remains a significant challenge, with current treatments inadequately addressing all patient needs.
  • Identifying molecular mechanisms underlying pain is crucial for developing targeted therapies.
  • Advances in technology necessitate an updated review of proteomic and genomic findings in pain research.

Purpose of the Study:

  • To review recent proteomic and genomic studies on various pain types.
  • To analyze the role of identified genes and proteins in pain signaling pathways.
  • To evaluate the potential of these findings for novel pain therapeutic strategies.

Main Methods:

  • Comprehensive literature review of proteomic and genomic approaches in pain research.
  • Analysis of identified genes and proteins involved in pain-related pathways.
  • Evaluation of experimental approaches, including animal models and genetic association studies.

Main Results:

  • Genomics and proteomics have identified numerous genes and proteins implicated in pain pathways.
  • These molecular mediators offer potential as diagnostic markers and drug targets.
  • Novel therapeutic strategies for individualized pain management are emerging.

Conclusions:

  • Proteomic and genomic research is vital for advancing pain management.
  • Identifying molecular targets can improve the efficacy and specificity of pain treatments.
  • Future research should focus on robust experimental designs and population studies for clinical translation.

More Related Videos

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...