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Updated: Jun 17, 2026
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Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
Liver transplantation in children using non-heart-beating donors (NHBD)
S Gozzini1, M T P R Perera, D A Mayer
1The Liver Unit, Birmingham Children's Hospital, Birmingham, UK.
Pediatric Transplantation
|January 15, 2010
Summary
Pediatric liver transplants using deceased donor grafts show excellent outcomes. This study confirms the safety and efficacy of utilizing these grafts in children, with 100% survival rates.
Area of Science:
- Hepatology
- Transplantation Surgery
- Pediatric Gastroenterology
Background:
- Adult liver transplantation (OLT) using non-heart-beating donors (NHBD) has demonstrated good medium-term results.
- The application and outcomes of NHBD liver grafts in pediatric OLT require further investigation.
Purpose of the Study:
- To evaluate the safety and efficacy of pediatric OLT using whole and partial grafts from NHBD.
- To analyze complications and outcomes in children undergoing OLT with NHBD liver grafts.
Main Methods:
- Retrospective review of pediatric patients who underwent primary OLT between December 2005 and December 2008 using NHBD livers.
- Analysis included donor and recipient demographics, graft types (whole vs. reduced), warm ischemia time (WIT), cold ischemia time (CIT), and post-transplant complications.
- Graft function was assessed via liver function tests at one week and nine months post-OLT.
Main Results:
- Four children (mean age 9.5 years) received OLT with NHBD grafts (two whole, two reduced).
- Mean donor age was 14.2 years, mean WIT was 12.2 minutes, and mean CIT was 7.18 hours.
- Excellent graft function was observed one week and nine months post-OLT. One patient experienced acute rejection, and two had mild ischemic cholangiopathy, both managed conservatively.
- Graft and patient survival rates were 100% with a mean follow-up of 19 months.
Conclusions:
- Pediatric OLT with NHBD liver grafts is safe and effective.
- Short warm and cold ischemia times are crucial for successful outcomes in pediatric liver transplantation using NHBD grafts.
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