Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Accessory Structures of the Eye01:17

Accessory Structures of the Eye

Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rhabdomyoma of paracarotid space: case report.

Frontiers in surgery·2026
Same author

Early timepoint <sup>99m</sup>Tc-DPD whole body scintigraphy and quantitative SPECT/CT imaging for diagnosis of cardiac ATTR amyloidosis.

EJNMMI research·2026
Same author

[Position paper of the German Society of Cardiology-quality criteria for performing catheter ablation of atrial fibrillation: executive summary].

Herzschrittmachertherapie & Elektrophysiologie·2026
Same author

Prognostic parameters and detection of cardiac amyloidosis with hybrid <sup>18</sup>F-Florbetaben-PET/MRI: an exploratory observational study.

European journal of nuclear medicine and molecular imaging·2026
Same author

Current treatment decisions in cardiac transthyretin amyloidosis: a multicentre analysis.

Clinical research in cardiology : official journal of the German Cardiac Society·2026
Same author

Nuclear cardiology - Current status of the clinical application.

Nuklearmedizin. Nuclear medicine·2026

Related Experiment Video

Updated: Jun 17, 2026

Three-Dimensional Reconstruction of Orbital Fractures
08:18

Three-Dimensional Reconstruction of Orbital Fractures

Published on: May 16, 2025

Orbital involvement in Castleman disease.

Ioannis Venizelos1, Thomas G Papathomas, Maria Papathanasiou

  • 1Department of Pathology, Hippokration General Hospital of Thessaloniki, Thessaloniki, Greece.

Survey of Ophthalmology
|January 15, 2010
PubMed
Summary

This study details the first biopsy-proven case of multicentric Castleman disease in the orbit of an HIV-negative, HHV-8-negative man. Orbital Castleman disease is rare but should be considered in orbital mass diagnoses.

Related Experiment Videos

Last Updated: Jun 17, 2026

Three-Dimensional Reconstruction of Orbital Fractures
08:18

Three-Dimensional Reconstruction of Orbital Fractures

Published on: May 16, 2025

Area of Science:

  • Oncology
  • Pathology
  • Ophthalmology

Background:

  • Castleman disease is a rare lymphoproliferative disorder, typically affecting lymph nodes.
  • Extranodal involvement is uncommon, making orbital presentation exceptionally rare.

Observation:

  • A 70-year-old, HIV-seronegative, HHV-8-unassociated man with Parkinson disease presented with orbital Castleman disease.
  • Diagnosis confirmed via morphologic, immunophenotypic, and molecular analysis of lymph node and orbital tissue biopsies.

Findings:

  • This is the first reported case of biopsy-proven multicentric plasma cell Castleman disease involving the orbital region.
  • A review of existing literature on orbital Castleman disease highlights its unique characteristics and associations.

Implications:

  • Orbital Castleman disease, though rare, can present with initial ocular symptoms.
  • It warrants inclusion in the differential diagnosis for orbital mass lesions.