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Pathogen incidence and antibiotic resistance patterns of catheter-associated urinary tract infection in children

Xue-Cheng Bi1, Binghua Zhang, Yong-Kang Ye

  • 1Southern Medical University, Guangzhou, China.

Journal of Chemotherapy (Florence, Italy)
|January 15, 2010
PubMed

Insights

In children with catheter-associated urinary tract infections (CAUTI), Gram-negative bacteria like E. coli are common pathogens. Optimizing antibiotic therapy requires understanding local pathogen susceptibilities to guide effective treatment.

Area of Science:

  • Pediatric Infectious Diseases
  • Antimicrobial Resistance
  • Clinical Microbiology

Background:

  • Catheter-associated urinary tract infections (CAUTI) are a significant concern in hospitalized children.
  • Understanding the specific pathogens and their antibiotic susceptibility patterns is crucial for effective management.

Purpose of the Study:

  • To characterize the common pathogens causing CAUTI in children in China.
  • To determine the antibiotic susceptibility profiles of these pathogens.
  • To inform and optimize empirical antibiotic therapy and prophylaxis strategies for pediatric CAUTI.

Main Methods:

  • A retrospective study involving 895 children with indwelling catheters from 2001 to 2006 across three hospitals in China.
  • Antimicrobial susceptibility testing was performed on 450 bacterial isolates using CLSI broth and Kirby-Bauer agar dilution methods.
  • Data analysis focused on identifying prevalent uropathogens and their resistance patterns.

Main Results:

  • 37.4% of children developed CAUTI.
  • Escherichia coli was the most frequent pathogen, followed by Staphylococcus aureus, Staphylococcus epidermidis, and Enterococcus spp.
  • E. coli showed high susceptibility to ceftazidime, cefuroxime, and cefatrizine, but low susceptibility to sulfamethoxazole, amoxicillin, and ampicillin. Gram-negative species predominated.

Conclusions:

  • Gram-negative bacteria are the primary cause of CAUTI in the studied pediatric population in China.
  • Knowledge of local bacterial spectrum and antibiotic susceptibility is essential for improving empirical treatment of CAUTI in children.
  • Tailoring antibiotic choices based on susceptibility data can enhance treatment efficacy and combat antimicrobial resistance.

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