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[Gene expression based multigene prognostic and predictive tests in breast cancer]
Zsófia Pénzváltó1, Zsuzsanna Mihály, Balázs Gyorffy
1Magyar Tudományos Akadémia és Semmelweis Egyetem Gyermekgyógyászati és Nefrológiai Kutatócsoportja I. Gyermekklinika 1083 Budapest Bókay u. 53/54. penzvaltozsofi@gmail.com
Magyar Onkologia
|January 15, 2010
Summary
Future cancer treatment relies on personalized therapies. Multigene assays offer comprehensive tumor characterization, but require further validation and cost reduction for widespread clinical use.
Area of Science:
- Oncology
- Molecular Diagnostics
- Genomics
Context:
- Personalized cancer therapy requires precise tumor characterization.
- Multigene assays offer simultaneous diagnostic and prognostic information.
- Current assays include RT-PCR and microarray-based platforms.
Purpose:
- To summarize available RT-PCR and microarray-based multigene assays for cancer.
- To highlight the potential of multigene assays in personalized medicine.
- To identify limitations of current multigene testing.
Summary:
- This review covers multigene assays like MammaPrint and Oncotype DX.
- These tests aid in predicting cancer treatment response.
- Key challenges include poor validation, high costs, and complex bioinformatics.
Impact:
- Multigene assays are crucial for advancing tailored cancer treatment strategies.
- Addressing current limitations will enhance the clinical utility of these diagnostic tools.
- Improved validation and cost-effectiveness are essential for broader adoption.
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