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Octyl methoxycinnamate modulates gene expression and prevents cyclobutane pyrimidine dimer formation but not

Nur Duale1, Ann-Karin Olsen, Terje Christensen

  • 1Department of Chemical Toxicology, Division of Environmental Medicine, Norwegian Institute of Public Health, Nydalen, NO-0403 Oslo, Norway.

Toxicological Sciences : an Official Journal of the Society of Toxicology
|January 15, 2010
PubMed

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DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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